In addition, because of ease of cell propagation, high efficiency for DNA transfection, sensitivity to RNA interference, possession of receptors for many relevant ligands, and other properties, RAW264.7 has been chosen by the Alliance for Cellular Signaling as the primary experimental system for their large-scale study of signaling pathways.
Further, in studies of a mouse model of severe respiratory disease, RAW264.7 was found to be uniquely efficient for propagation of the causative agent, pneumonia virus of mice, and for measuring infection-related proinflammatory mediators. In contrast to most other mouse-derived cell cultures, the macrophage-like cell line RAW264.7 supports replication of murine noroviruses and is widely used for this purpose.
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